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 The Safe Laser devices can be used for investigated disorders (diseases diagnosed by doctors), and it is recommended that only persons 18 years of age and older use the lasers. Do not use the nasal mucosa lightening method on babies and young children due to the relatively powerful light which may prove irritating to the eyes.

Irradiation of the lower abdomen or the nasal mucosa in the case of pregnant women and open fontanelles in the case of infants is prohibited due to congestion (potentially dangerous) increase. For individuals suffering with severe blood clotting problems, use of the device is also not recommended. Further, it is suggested that users do not illuminate malignant tumors, thyroid and breast areas or fungal skin surfaces.

Direct radiation of paint moles can be dangerous because it is considered to be a pre-cancerous condition.

The lasers should never be pointed directly into the eyes.